久久久精品欧美一区二区三区,国产欧美久久久精品影院,亚洲AV福利天堂一区二区三亚洲欧洲日韩国产AⅤ在线,亚洲成av人在线视,四虎国产精品永久地址99自拍三区一级国产片,亚洲男人的天堂久久无在线观看免费黄视频,亚洲一级特黄大片在线播放,国产成人精品区在线观看

Vaccine
Home > Application > Vaccine > Virus-like particle (VLP) vaccine

Virus-like particle (VLP) vaccine

Most currently available vaccines are mainly based on inactivated or attenuated live vaccines. Although these traditional vaccines have been used effectively against various infectious diseases, some of them have several limitations, including low likelihood of inducing a stronger immune response and their poor efficacy. Recent outbreaks of infectious diseases demonstrate the need to develop robust vaccines to overcome these limitations. The main challenge is to develop new technical approaches and boost immunity without compromising safety, efficacy and tolerability. Recent advances in vaccines based on DNA, mRNA, and recombinant viral vectors provide effective vaccine development methods for difficult-to-target pathogens and control infectious disease outbreaks.


Virus-like particle (VLP) technology provides an alternative platform for the development of effective vaccines against serious infectious diseases, and it is being developed in parallel with vaccines based on mRNA and viral vectors. VLPs are also much more immunogenic than other subunit vaccines because they present repetitive epitopes on their surface, making them more reliably detectable by the immune system. On the other hand, subunit vaccines may be less immunogenic due to misfolding of the target antigen or insufficient presentation to the immune system, and moreover, they require adjuvants and repeated vaccinations to elicit an adequate immune response. The term virus-like particle was first described by Fraenkel-Conrat and Williams (1955) by recombining tobacco mosaic virus (TMV) particles from purified RNA and protein components. The potential of these nanostructures to induce potent immune responses was then further investigated. The VLP platform can overcome various problems typically associated with traditional vaccines; specifically, infectivity, reversion to virulent forms, mutation risk associated with live attenuated vaccines, and reduced immunogenicity, toxicity instability, low yield and long formulation time associated with inactivated vaccines.


These bio-inspired nanostructures feature repetitive and high-density antigens from different viruses, helping to trigger a strong immune response. Furthermore, these highly immunogenic molecules possess the self-assembling properties of viral proteins. They are biocompatible and have the potential for structural flexibility during synthesis. They can be chemically or genetically modified and exhibit increased stability, uniformity, and functionality, and are considered effective tools in various biomedical applications. Depending on the presence or absence of a lipid membrane, VLPs can be classified as either enveloped or nonenveloped.


However, some of the key challenges associated with VLPs are low stability, difficult downstream processes, high production costs, and sensitivity to environmental conditions. Many different VLPs have been synthesized in various expression systems, such as bacteria, yeast, mammalian cells, insect cells, and plants. VLP-based vaccines have the potential to be used to treat various infectious diseases, including HIV, influenza, hepatitis B, hepatitis E, malaria, Ebola virus, SARS-CoV-2, Zika virus, dengue fever, and foot-and-mouth disease, among others. Several VLP-based vaccines have been licensed and marketed, including Engerix-B? and Recombivax HB? for HBV, Gardasil? and Cervarix? for HPV, Hecolin? for HEV, and Mosquirix? for malaria.

Related Products
Contact Us
  • Tel.: +86 021 6434 0155
  • E-Mail: marketing@duoningbio.com
  • Address: Building 30, No. 1525 Minqiang Road, Songjiang District, Shanghai
Message

Copyright ? Shanghai Duoning Biotechnology Co., Ltd. All Rights Reserved Sitemap | Technical Support: Reanod

WeChat
WeChat

Message-

Duoning Biotechnology

+86 021 6434 0155

日韩一区二区三区免费| 精品国产AV最大网站| 九九精品免视频国产成人| 无码4800YY私人影院在线看| 日韩乱码人妻无码中文视频| 久久精品亚洲乱码伦伦中文| 亚洲乱码国产一区三区久久午夜无码鲁丝片| 人人爽夜夜爽天天喷水| 久久精品国产99久久久古代| 波多野结衣绝顶大高潮| 国产欧美日韩久久久久| 日韩精品一区二区三区视频在线观看| 精品国产鲁一鲁一区二区交| 在线天堂中文最新版网| 色多多A级毛片免费看| 人妻91麻豆一区二区三区| 国产午夜精品理论在线观看| 最近中文在线字幕在线观看| 伊人影院国产在线视频不卡一| 精品无码成人久久久久久| 免费国产成人福利在线观看网址| 久久国产V一级毛多内射孕妇| 好妈妈在线观看完整版| 无码人妻精品一区二区三区久久久| 亚洲欧美日韩综合俺去了| 波多野结衣一区二区免费视频| 国产A∨国片精品青草视频| 国产又粗又黄又爽又硬的视频| 久久亚洲精品无码观看不卡| 亚洲午夜福利717亚洲国产区男人| 2021777久久人妻少妇嫩草AV| 国产成人久久久精品二区三区| 97视频人人看人人做首页一97碰| 2021国产v亚洲v天堂无码| 两个奶头被吃高潮视频| ?愛妃?国产一区二区三区视频精品| 99热门精品一区二区三区无码| 久久毛片免费全部播放无码| 日韩国产欧美综合网| 又粗又大又硬毛片免费看| 麻豆蜜桃91无码专区在线观看|